90-day oral toxicity study of a salmon nasal cartilage extract containing undenatured collagen and proteoglycan in Sprague-Dawley rats.

ABSTRACT: Salmon nasal cartilage is a rich source of proteoglycan and collagen that is widely used in food products. In Japan, a novel extraction method has been developed and patented that enable the simultaneous production of proteoglycan and undenatured collagen from salmon nasal cartilage. This study evaluated the subchronic oral toxicity of this extract mixture (SCP Complex-LS, containing 40% proteoglycan and 40% undenatured collagen) in a 90-day repeated toxicity study in Sprague-Dawley rats, following by a 14-day recovery period. Rats (20/group; 10 males and 10 females) were administered SCP Complex-LS once daily by oral gavage at doses of 0 (vehicle), 10.3, 20.6, or 41.2 mg/kg body weight/day, with additional recovery groups (10/groups; 5 males and 5 females) receiving vehicle or the high do

SUBMITTER: Takada K 

PROVIDER: S-EPMC12829970 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature