Computational modelling identifies key determinants of subregion-specific dopamine dynamics in the striatum.

ABSTRACT: Striatal dopamine (DA) release regulates reward-related learning and motivation and is believed to consist of a short-lived phasic and continuous tonic component. Here, we build a large-scale three-dimensional model of extracellular DA dynamics in dorsal (DS) and ventral striatum (VS). The model predicts rapid dynamics in DS with little to no basal DA and slower dynamics in the VS enabling build-up of tonic DA levels. These regional differences do not reflect release-related phenomena but rather differential dopamine transporter (DAT) activity. Interestingly, our simulations posit DAT nanoclustering as a possible regulator of this activity. Receptor binding simulations show that D1 receptor occupancy follows extracellular DA concentration with milliseconds delay, while

SUBMITTER: Ejdrup A 

PROVIDER: S-EPMC12829992 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature