Single-cell transcriptome sequencing revealing the microenvironment of breast fibroepithelial tumor.

ABSTRACT:

Background

Giant juvenile fibroepithelial tumors of the breast are rare lesions that mainly affect adolescent girls. Their pathogenesis is poorly understood, and current management relies almost entirely on surgery, which may interfere with breast development. To clarify the biological basis of these tumors, we performed single-cell RNA sequencing.

Methods

We profiled 15,295 cells from three juvenile cases (ages 12-16) and 11,442 cells from one adult patient (age 42) using the BD Rhapsody™ platform. This dataset provided a detailed cellular atlas of fibroepithelial lesions and enabled direct comparison of tumor microenvironments between juvenile and adult cases.

Results

Distinct molecular signatures in epithelial cells and fibroblasts: Juvenile FT epithelial cells exh

SUBMITTER: Shu T 

PROVIDER: S-EPMC12830078 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature