Fructose-sweetened beverages induce diurnal redox dysregulation in pediatric MASLD.

ABSTRACT:

Background

Plasma glutathione/glutathione disulfide (GSH/GSSG) and cysteine/cystine (Cys/CySS) redox couples undergo diurnal variation in adults and are more oxidized in obesity-related conditions, including metabolic dysfunction-associated steatotic liver disease (MASLD). There is limited research on redox in children and no data on redox responses to sugars, despite high sugar consumption in this population. This study aimed to describe the diurnal variation of redox couples in children, assess the impact of MASLD, and evaluate responses to fructose versus glucose beverages.

Methods

In a 2-day randomized, controlled, crossover feeding study, 26 children (12 with MASLD, 14 controls; aged 10-18 years) consumed isocaloric meals with fructose beverages (FB) on one day and gluc

SUBMITTER: Huneault HE 

PROVIDER: S-EPMC12830102 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature