Natural History and Risk Stratification of Biochemically Recurrent Prostate Cancer Following Definitive Radiation Therapy.

ABSTRACT:

Purpose

Among patients with biochemical recurrent (BCR) prostate cancer following radiation therapy, there is no validated method for identifying those at the highest risk for metastases or death from prostate cancer. We characterized the natural history of BCR after radiation therapy and validated the proposed European consensus guidelines for stratification.

Methods and materials

This retrospective, multicenter, nationwide cohort study used data from patients having postradiation BCR treated in the United States Veterans Administration Health System. High-risk BCR was defined as either Gleason score ≥8 or BCR occurring within 18 months of radiation therapy, per guidelines.

Results

Among 7126 patients who experienced BCR, 35.5% of patients developed metastatic diseas

SUBMITTER: Riviere P 

PROVIDER: S-EPMC12830108 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature