Prediction of Postoperative Intravesical Recurrence Using Urine DNA Monitoring in Nonmuscular-Invasive Urothelial Bladder Cancer.

ABSTRACT:

Objectives

Considering the high frequency of intravesical recurrence in bladder urothelial carcinoma (UBC), accurate non-invasive biomarkers for recurrence prediction are needed for better management after transurethral surgery. This pilot study examined the usefulness of urine DNA for detecting and predicting intravesical recurrence in UBC.

Methods

Patients with primary nonmuscle-invasive UBC were prospectively enrolled just after initial transurethral surgery. Genomic profiles were evaluated in resected specimens of the original tumor and in urine during follow-up. Urine DNA, urine cytology, and cystoscopy were all evaluated at 3-month intervals until 1 year postoperatively. Upon centrifuging urine samples into precipitation and supernatant fractions, we retrospectively ev

SUBMITTER: Shiozaki M 

PROVIDER: S-EPMC12830168 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature