Multi-omics reveals co-regulation of hepatic bile acid metabolism in laying hens by host genetics and the cecal Anaerostipes.

ABSTRACT: Bile acids (BA) are central regulators of lipid metabolism and key signaling molecules within the gut-liver axis. Dysregulation of BA is implicated in fatty liver hemorrhagic syndrome (FLHS), a prevalent metabolic disorder in laying hens characterized by hepatic lipid accumulation, hemorrhage, reduced egg production, and increased mortality. However, the mechanisms governing BA regulation in poultry remain poorly understood. Here, we integrated multi-omics analyses to dissect how host genetics and gut microbiota interact to modulate hepatic total bile acids (HTBA) levels. A total of 686 hens at 90 weeks of age were profiled for HTBA, free fatty acids (FFA), triglycerides (TG), and total cholesterol (TC). We integrated single-nucleotide polymorphism (SNP)-based genome-wide association studi

SUBMITTER: Yang W 

PROVIDER: S-EPMC12830193 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature