Genome-wide association studies in chronic venous disease: A systematic review.

ABSTRACT:

Background

Chronic venous disease (CVD) arises from venous hypertension secondary to impaired venous return, causing significant morbidity and diminished quality of life. Genetic factors are likely important in the pathogenesis and susceptibility of a patient to develop CVD. This systematic review summarizes genome-wide association studies (GWASs) that investigate the link between genetic variants and CVD.

Methods

A systematic review was conducted in accordance with the PRISMA guidelines, with the search dates ranging from January 1, 1994, to July 17, 2025. Abstract and full-text screening were completed by two independent reviewers, with any conflicts referred to a third senior reviewer. GWASs in adults investigating links between genetic variants and CVD were included. Exc

SUBMITTER: Soh CL 

PROVIDER: S-EPMC12830204 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature