Exosomal miRNA-218-5p derived from low-passage dermal papilla cells modulates hair follicle growth and development.

ABSTRACT: Exosomes are nanoscale particles that participate in multiple biological processes and are secreted by various cell types. Exosomes derived from dermal papilla cells (DPC-Exos) regulate hair follicle (HF) growth and development. In this study, HF development-related genes were significantly expressed in low-passage dermal papilla cells (DPCs). Low-passage DPC-Exos promoted hair follicle stem cell (HFSC) proliferation. After the collection of DPC-Exos, miRNA sequencing identified 36 differentially expressed (DE) miRNAs between low-passage and high-passage DPC-Exos. Among these, miR-218-5p was significantly upregulated in low-passage DPC-Exos and dysregulated HF growth and development-related gene expression in HFSCs. Furthermore, the transport mechanism of exosomal miR-218-5p from DPCs is i

SUBMITTER: Zhao B 

PROVIDER: S-EPMC12830253 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature