Perioperative tranexamic acid in burn surgery: systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Introduction

Burn injuries often require surgery, posing challenges due to significant intraoperative blood loss and transfusion risks. Tranexamic Acid (TXA), an antifibrinolytic agent, stabilizes clots and reduces fibrinolysis, with proven efficacy in various surgical settings. However, the benefits in burn patients are yet to be established.

Methods

We performed a systematic review and meta-analysis. PubMed, Embase, and Cochrane databases were searched for Randomized Clinical Trials (RCTs) comparing TXA versus control in burned patients. Risk Ratios (RR) and Mean Differences (MD) with 95% CIs were computed for binary and continuous outcomes, respectively. The primary endpoint of interest was blood loss. Statistical analyses were performed using RStudio software (version 4.

SUBMITTER: Molinari ME 

PROVIDER: S-EPMC12830265 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature