Transferrin-modified multicomponent liposomes encapsulating paclitaxel-loaded <i>β</i>-elemene microemulsion enhance therapeutic efficacy in non-small-cell lung cancer.

ABSTRACT: To achieve efficient accumulation and facilitate profound penetration of anti-tumor agents within neoplastic tissues stands as one of the most critical determinants influencing the efficacy of anticancer therapies. Herein, a multicomponent-based liposomes (Tf-PEM/L) by transferrin-modified encapsulating paclitaxel (PTX)-loaded β-elemene microemulsion (PEM) was fabricated, demonstrating significantly enhanced therapeutic efficacy against non-small cell lung cancer (NSCLC). Leveraging the synergistic mechanism of transferrin-mediated active targeting coupled with the enhanced permeability and retention (EPR) effect, Tf-PEM/L demonstrates a pronounced propensity for efficient and substantial accumulation at the tumor site. Following accumulation, the subsequently released PEM enables h

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12830280 | biostudies-literature | 2026 Jun

REPOSITORIES: biostudies-literature