A microfluidic model of human dental pulp angiogenesis for preclinical drug and biomaterial testing.

ABSTRACT: Dental pulp homeostasis and regeneration critically depend on angiogenesis, the formation of new capillaries from preexisting blood vessels. Regenerative endodontics has emerged as a clinical strategy to restore damaged or diseased dental pulp tissues using stem cells, signalling molecules, and scaffolds. Enhanced cell viability and angiogenesis are essential for the success of such regenerative therapies. However, their development, as well as efficient drug and biomaterial testing, is limited by the lack of physiologically relevant models. In this study, we developed a microfluidic model of angiogenesis in the human dental pulp to investigate the effects of drugs and biomaterials commonly used in dentistry. We optimised culture conditions influencing angiogenic sprouting and found that t

SUBMITTER: Svanberg S 

PROVIDER: S-EPMC12830287 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature