Distinct commensal bacteria in human nasopharyngeal lymphoid tissue associated with localized immunological memory.

ABSTRACT: The nasopharynx (NP) serves as a primary site for localized immune responses that restrict the spread of SARS-CoV-2 to the lower respiratory tract. The microbiome is increasingly recognized as a key modulator of antiviral immunity but whether it shapes immune responses in upper airway remains uncharacterized. Detailed microbial profiles revealed that S. aureus complex abundance was the primary discriminating factor of microbial community in the NP and the enhanced abundance of S. aureus complex correlated with higher frequencies of CD4⁺, CD8⁺ tissue-resident memory T (T_RM), and B_RM cells. The abundance of S. aureus complex was closely associated with distinct metabolic pathways, particularly those involve

SUBMITTER: Park ST 

PROVIDER: S-EPMC12830300 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature