Association between antimicrobial use and the detection rates of carbapenem-resistant Enterobacterales: long-term surveillance results from a single centre.

ABSTRACT:

Background

Carbapenems are vital for treating Enterobacterales infections. However, the emergence of carbapenem-resistant Enterobacterales (CRE), mediated by carbapen-emases or otherwise, has become a global concern due to increased morbidity and mortality. In Japan, metallo-β-lactamase was found to be the predominant carbapenemase, notably imipenemase. Both carbapenem-susceptible and carbapenem-resistant strains of carbapenemase-producing Enterobacterales exist, which complicates the identification of carbapenemase production through susceptibility testing alone. Infection control measures, such as contact precautions and antimicrobial stewardship, are recommended to combat resistant strains. Since carbapenem use is a risk factor for resistance, reducing its consumption is a key s

SUBMITTER: Hirayama S 

PROVIDER: S-EPMC12830325 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature