First evaluation in multiple sclerosis using PET tracer [¹⁸F]3F4AP demonstrates heterogeneous binding across lesions.

ABSTRACT:

Purpose

Multiple sclerosis is characterized by demyelination and axonal loss in the central nervous system. While magnetic resonance imaging (MRI) is sensitive to myelin changes, conventional sequences lack specificity and cannot reliably distinguish demyelinated lesions with varying axonal integrity. We evaluated the potential of [¹⁸F]3F4AP, a novel positron emission tomography (PET) tracer and a radiolabeled derivative of 4-aminopyridine, to provide unique insights into demyelination in multiple sclerosis.

Methods

Three people with multiple sclerosis and three healthy controls underwent 2 h dynamic PET scanning with arterial blood sampling after administration of 296 MBq of [¹⁸F]3F4AP and 3T MRI. MRI sequences included T1 Magnetization Prepared Rapid

SUBMITTER: Tiss A 

PROVIDER: S-EPMC12830403 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature