Evaluation of end-to-end 3D absorbed dose distribution in ⁹⁰Y-SIRT and SBRT combination therapy using MAGIC-f polymer gel dosimeter.

ABSTRACT:

Background

Selective Internal Radiation Therapy (SIRT) with ⁹⁰Y-microspheres, and Stereotactic Body Radiation Therapy (SBRT), are well-established treatment strategies for liver malignancies. Combining these two modalities has proven to be an effective and safe approach for addressing undertreated tumor regions from initial SIRT through a boost dose from SBRT. The complex dosimetry process, which includes image-based dosimetry of ⁹⁰Y-SIRT and SBRT dose painting, requires precise dosimetry verification. In this study, gel dosimetry is proposed as a valuable novel tool to capture the 3D absorbed dose contributions from both treatments with high spatial resolution.

Methods

The MAGIC-f polymer gel dosimeter was used in three experiments: external beam radia

SUBMITTER: Mansouri Z 

PROVIDER: S-EPMC12830405 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature