Biological tumor volume predicts survival in recurrent High-Grade glioma: A multiparametric [¹⁸F]FET PET/MRI study.

ABSTRACT:

Background and purpose

Single-session, multiparametric [¹⁸F]FET PET/MRI is used to detect tumor recurrence in high-grade glioma, but its prognostic value for overall survival remains uncertain. This study evaluated whether biological tumor volume, tumor-to-background ratio (TBRmax), cerebral blood volume (rCBVmax), and choline/NAA ratio (Cho/NAA) could predict survival in recurrent high-grade glioma.

Materials and methods

Twenty-six patients with histopathologically confirmed tumor progression underwent simultaneous [¹⁸F]FET PET/MRI. PET-derived biological tumor volume and TBRmax, MRI-derived rCBVmax, and Cho/NAA ratio were analyzed. A Cox proportional hazards model assessed associations with overall survival, adjusting for the number of lesions and treatment strategy.

Re

SUBMITTER: Henssen D 

PROVIDER: S-EPMC12830414 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature