ZBP1 Mediates Renal Tubular Injury in Diabetic Nephropathy Through RIPK3-mediated Necroptosis.

ABSTRACT: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Given the limited therapeutic options, identifying novel differentially expressed genes and therapeutic targets is crucial for DN. We performed transcriptome sequencing of kidney tissue from DN patients and applied bioinformatics analyses to identify dysregulated pathways and candidate genes. Transcriptomic analysis revealed significant enrichment of the necroptosis pathway in DN kidney tissues, with Z-DNA binding protein 1 (ZBP1) showing the most pronounced differential expression among pathway-associated genes. Clinical and pathological data were collected from DN patients to evaluate the correlation between ZBP1 expression and key indicators of renal function and injury, thereby assessing its association with DN

SUBMITTER: Hu Z 

PROVIDER: S-EPMC12830419 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature