A gene-expression signature defines a subtype of Stomach Adenocarcinomas with low levels of Claudins and a high ratio of NF-YA long/NF-YA short splicing variants.

ABSTRACT:

Background

Claudin-3, Claudin-4, and Claudin-7 are expressed on the surface of epithelial cells. Their absence in neoplastic cells of epithelial origin is an aggressiveness marker in different cancers. The NF-YA gene codes for the Nuclear-Transcription-Factor-Y-Subunit-A, which is overexpressed in various tumors. In tumors, the relative ratio of the two major NF-YA alternative splicing isoforms, NF-YA long and NF-YA short, is associated with a mesenchymal phenotype and a poor prognosis. Based on a high NF-YA long/NF-YA short ratio, we generated a 158-gene signature that is common to Claudin^low Breast Carcinomas (BRCA) and Stomach Adenocarcinomas (STAD).

Methods

To better classify STAD Claudin^low tumors, we employed a hierarchical clustering approach bas

SUBMITTER: Gallo A 

PROVIDER: S-EPMC12830421 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature