[⁶⁸Ga]Ga-NODAGA-RGD post MI reflects activated fibroblasts rather than angiogenesis.

ABSTRACT:

Purpose

Angiogenesis is crucial in myocardial healing after myocardial infarction (MI). The α_vβ₃-integrin, a key regulator of angiogenesis, is targeted by RGD-based PET tracers like [⁶⁸Ga]Ga-NODAGA-RGD. Yet, angiogenesis imaging using RGD-based tracers is seriously hampered by the lack of true specificity of the α_vβ₃-integrin for angiogenic cells. Therefore, our study aimed to identify the cell type with the highest α_vβ₃-integrin expression in the process of myocardial healing in order to determine the actual value of the PET tracer [⁶⁸Ga]Ga-NODAGA-RGD for imaging post-MI angiogenesis.

Methods

Cardiac magnetic resonance imaging (CMR) was used to assess cardiac function and morphology afte

SUBMITTER: Raitza M 

PROVIDER: S-EPMC12830458 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature