Burden of gastric cancer attributable to Helicobacter pylori in 27 countries from seven geographic regions in 2022.

ABSTRACT:

Background

Helicobacter (H.) pylori is the major risk factor of gastric cancer (GC). We aimed to estimate the population attributable fraction (PAF) of GC and the number of new GC cases and deaths for GC attributable to H. pylori in different countries worldwide in 2022.

Methods

The PAF was estimated using country-specific pooled prevalence of H. pylori in the period 2000-2010 obtained through a systematic review and meta-analysis and a risk ratio of 5.9 for the association between H. pylori and GC. The absolute number of new GC cases and deaths for GC attributable to H. pylori was calculated using PAF and GC incidence and mortality reported by GLOBOCAN 2022.

Results

The PAF of GC due to H. pylori was calculated for 27 countries. The average PAF was 69.7% ranging from

SUBMITTER: Collatuzzo G 

PROVIDER: S-EPMC12830462 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature