Early synaptic pathology is associated with small tau aggregates in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is phenotypically characterised by progressive memory loss, which has been linked to tau aggregation and synaptic dysfunction. Here we characterised the nanoscopic tau aggregates in individual synaptosomes from AD cases and controls, measuring their number and size using SynPull with direct stochastic optical reconstruction microscopy (dSTORM). A total of 7888 synaptosomes from pre-frontal cortex samples were studied, showing the presence of AT8-positive tau aggregates in a small fraction of synaptosomes (~ 3%) from control brains, reaching ~ 20% by Braak stage 6. These key findings of the intra-synaptic localisation of aggregates and existence of synaptic tau pathology at Braak stage 3-preceding tangle formation in this region, were confirmed using aggregate-speci

SUBMITTER: Fertan E 

PROVIDER: S-EPMC12830486 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature