Quantification of monoamine oxidase B expression with ¹¹C-SL25.1188 for imaging reactive astrocytes in patients with Alzheimer's disease.

ABSTRACT:

Purpose

Astrocyte reactivation can be assessed using positron emission tomography (PET) ligands targeting monoamine oxidase B (MAO-B). ¹¹C-SL25.1188 binds reversibly to MAO-B, allowing precise density measurements, but requires invasive arterial sampling. This study aimed to develop a simplified, noninvasive method to quantify MAO-B with ¹¹C-SL25.1188 PET in Alzheimer's disease (AD).

Methods

Six patients with mild cognitive impairment (MCI), five patients with AD, and six healthy controls (HCs) underwent ¹¹C-SL25.1188 PET scans. The distribution volume ratios (DVRs) were calculated and compared using two methods: the original multilinear reference tissue model (MRTM_O) and the Logan plot. Changes in MAO-B densities, plasma glial fib

SUBMITTER: Matsuoka K 

PROVIDER: S-EPMC12830491 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature