Clinical evaluation of tissue-dependent and spatially-variant positron range correction for Gallium-68 PET imaging.

ABSTRACT:

Purpose

Positron range correction (PRC) can mitigate the effect of the larger positron range on the image quality of Gallium-68 (⁶⁸Ga) PET-imaging. The aim of this study is to evaluate the improvement in ⁶⁸Ga-PET image quality by applying a tissue-dependent and spatially-variant PRC (TDSV PRC) for ⁶⁸Ga in a clinical setting.

Methods

A TDSV PRC technique was developed employing CT-driven segmentation masks of different tissue types (soft tissue, bone, lung) and the corresponding tissue-specific positron range kernels. OSEM reconstructions were performed using the proposed TDSV PRC, a tissue-independent PRC, and without any PRC (non-PRC). For lesions identified in [⁶⁸Ga]Ga-DOTATOC or [⁶⁸Ga]Ga-PSMA PET/CT data from 20 patie

SUBMITTER: Gavriilidis P 

PROVIDER: S-EPMC12830501 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature