Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress.

ABSTRACT:

Background

Endometrial Cancer (EC) is one of the most prevalent malignancies in the female reproductive system. Hypoxia is a hallmark of the tumor microenvironment that drives metabolic reprogramming, endoplasmic reticulum (ER) stress, and aggressive behavior in cancer cells. However, the underlying mechanisms remain incompletely understood. This study aimed to investigate hypoxia-mediated regulation of EC progression, focusing on the role of SLC9A7 (Solute Carrier Family 9 Member A7, NHE7).

Methods

EC cells were exposed to hypoxic conditions (1% O₂) to assess phenotypic changes. Transcriptomic analysis, RT-qPCR, and western blotting were utilized to identify hypoxia-induced targets. Functional assays (proliferation, migration, invasion, tumor spheroid formation)

SUBMITTER: Yang S 

PROVIDER: S-EPMC12830502 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature