Laparoscopic vs open gastrectomy after neoadjuvant chemotherapy for locally advanced gastric cancer: comparative short- and long-term outcomes.

ABSTRACT:

Background

Laparoscopic gastrectomy (LG) represents a technically challenging procedure for locally advanced gastric cancer (LAGC) after neoadjuvant chemotherapy (NAC). The safety and efficacy profiles of LG following NAC remain incompletely defined. This study aimed to compare short- and long-term outcomes between LG and open gastrectomy (OG) in NAC-treated LAGC patients.

Methods

We retrospectively analyzed consecutive LAGC patients undergoing LG or OG following NAC at our institution (Jan 2010-Dec 2019). Data from the prospectively maintained gastric surgery database were evaluated for demographic characteristics, operative parameters, perioperative morbidity, and oncological outcomes.

Results

Among 85 patients (46 LG, 39 OG), LG showed reduced blood loss, shorter h

SUBMITTER: Liang M 

PROVIDER: S-EPMC12830511 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature