Roles of KHDRBS2 and KHDRBS3 in prostate cancer progression and AR-V7 regulation.

ABSTRACT:

Objective

To investigate the biological functions of KHDRBS2 and KHDRBS3 in prostate cancer (PCa) progression and their potential roles in regulating androgen receptor splice variant 7 (AR-V7) expression, a key factor in castration-resistant prostate cancer (CRPC).

Methods

We performed a comprehensive analysis of publicly available datasets to examine the expression patterns of KHDRBS family members in PCa, including CRPC and neuroendocrine subtypes. In vitro experiments were conducted using AR-positive 22RV1 and AR-negative PC3 cell lines to assess the expression and regulatory interactions of KHDRBS2 and KHDRBS3. Functional assays evaluated their effects on cell proliferation and tumor growth in vivo. Additionally, KHDRBS2 protein levels were manipulated in 22RV1 cells to

SUBMITTER: Yang X 

PROVIDER: S-EPMC12830514 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature