Gender influences prognosis of classical BCR::ABL1 negative myeloproliferative neoplasms: a retrospective cohort study.

ABSTRACT:

Background

The prognostic value of gender in classical BCR::ABL1 negative myeloproliferative neoplasms (MPNs) including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) remains unclear.

Methods

We conducted a retrospective study utilizing the Surveillance, Epidemiology, and End Results (SEER) database to evaluate the prognostication of gender in MPNs patients. The Kaplan-Meier and Cox proportional hazards regression analysis were performed to calculate the survival outcomes of male and female patients with MPNs.

Results

Of 50,510 patients diagnosed with MPNs from 2000 - 2021, 24,583 patients (48.7%) were male and 25,927 patients (51.3%) were female. The Kaplan-Meier survival analysis revealed decreased overall survival in male aga

SUBMITTER: Cai Y 

PROVIDER: S-EPMC12830515 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature