Programmed cell death pathways coordinate neutrophil and macrophage clearance in zebrafish and are differentially exploited by Salmonella Typhimurium.

ABSTRACT: Programmed cell death (PCD) is essential for immune cell homeostasis and host defense, yet its role in neutrophil and macrophage elimination during bacterial infections remains poorly understood. Using the zebrafish model, which offers unique in vivo imaging and genetic manipulation advantages, we dissected the contribution of pyroptosis, apoptosis, and necroptosis to the regulation of neutrophil and macrophage fate during homeostasis and infection with Salmonella enterica serovar Typhimurium (ST). Under basal conditions, all three PCD pathways cooperated to control immune cell turnover. Upon infection, zebrafish larvae mounted a type III secretion system (T3SS)-independent emergency myelopoietic response that increased myeloid cell numbers. However, the pathogen rapidly counteracted this

SUBMITTER: Lozano-Gil JM 

PROVIDER: S-EPMC12830592 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature