Altered PTPN13-β-catenin interaction by pathogenic mutations and involvement of this axis in B-cell receptor signalling.

ABSTRACT: Protein tyrosine phosphatase non-receptor type 13 (PTPN13) is a non-receptor protein tyrosine phosphatase with context-dependent roles as tumour suppressor or promoter. Its modular structure supports multiple molecular interactions, including a critical one with β-catenin, a regulator of the haematopoietic system. We previously identified three pathogenic PTPN13 mutations in families with acute lymphoblastic leukaemia (ALL), anaemia, and/or inherited bone marrow failure (IBMF). Our current findings reveal that these mutations impair the PTPN13-β-catenin interaction. β-catenin and PTPN13 are stabilised upon B-cell receptor (BCR) activation, while PTPN13 silencing reduces Bruton's tyrosine kinase (BTK) activation and β-catenin levels, indicating that PTPN13 modulates BCR signalling at multip

SUBMITTER: Cabrera-Riofrio DA 

PROVIDER: S-EPMC12830625 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature