Social determinants of health, accelerated biological aging, and long-term health outcomes.

ABSTRACT: Social determinants of health (SDHs) are the primary drivers of health inequalities, but whether biological aging plays a role in linking SDHs to health outcomes remains unclear. Here we utilize detailed information on social determinants across five domains, clinical parameters and electronic health records from the UK Biobank and US NHANES to examine the associations between combined SDHs, accelerated biological aging, and health outcomes. Compared with participants in the favourable SDH group, participants in the unfavourable SDH group had increased KDM-BA and phenotypic age acceleration. Moreover, unfavourable SDHs were associated with elevated risks of mortality and incident diseases. Accelerated biological aging significantly mediated the association between SDHs and all-cause and ca

SUBMITTER: Li J 

PROVIDER: S-EPMC12830646 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature