The effect of high-dose long-term therapy of intravenous immunoglobulins in autoimmune autonomic and sensory small fiber neuropathy: a retrospective open-label controlled study.

ABSTRACT: Intravenous Immunoglobulins (IVIG) are used to treat autoimmune autonomic and sensory small fiber neuropathy (ASFN). The long-term effects of a high immunomodulatory dose of IVIG in ASFN remain unclear. This retrospective controlled study evaluated the long-term effects of high dose (2 g/kg/monthly) IVIG compared to usual treatment in patients with ASFN. Inclusion criteria were: Survey of Autonomic Symptoms (SAS) score ≥ 10, abnormal autonomic testing and skin biopsy, and positive inflammatory/autoimmune markers or a history of acute illness preceding autonomic symptoms. Quantitative Scale for Grading of Cardiovascular Autonomic Reflex Tests and Small Fibers from Skin Biopsies (QASAT) was used to grade tests. Patients were treated with IVIG until their condition improved and reached a plat

SUBMITTER: Novak P 

PROVIDER: S-EPMC12830657 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature