Impact of baseline visual acuity, time-in-range and early treatment on functional outcomes in DMO: insights from the IRISS outcomes.

ABSTRACT:

Background/objectives

The initial visual acuity (VA) prior to treatment initiation can significantly influence long-term visual outcomes. The current analysis aimed to examine change in VA by baseline vision categories and their effects on time spent within visual change categories in patients with diabetic macular oedema (DMO) who underwent treatment with the intravitreal fluocinolone acetonide (FAc) implant.

Subjects/methods

This was a post-hoc analysis of the IRISS-Registry Data. Time-in-range (TIR) was calculated based on three VA letter-score-thresholds: ≥70, ≥65, and ≥60 ETDRS letters after treatment initiation. TIR was stratified by baseline VA in three groups: 0-33, 34-68, and 69-100 letters. The primary outcome was the mean TIR for the ≥70 letters threshold (equival

SUBMITTER: Kozak I 

PROVIDER: S-EPMC12830729 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature