Oxindole based sulfonyl derivatives synthesized as potent inhibitors of alpha amylase and alpha glucosidase along with their molecular docking study.

ABSTRACT: Diabetes mellitus, a persistent metabolic disorder, impedes the proper metabolism of proteins, carbohydrates, and lipids, leading to various physiological complications. A spectrum of synthetic alpha-glucosidase inhibitors is employed to mitigate glucose levels; however, prolonged use of these medications has been associated with a range of adverse effects. The current study particularly focuses on piperidin-indolin based sulfonyl derivatives, a class of heterocyclic compounds to assess the inhibitory efficacy of these synthesized compounds against α-amylase and α-glucosidase enzymes. All compounds showed excellent inhibitory activity in the range between 1.90 ± 0.10 to 16.80 ± 0.30 µM (amylase) and 1.20 ± 0.01 to 15.40 ± 0.30 µM (glucosidase). Limited structural activity relationship has

SUBMITTER: Taha M 

PROVIDER: S-EPMC12830789 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature