Breath-based stratification of asthma severity using the MISTRAL platform with integrated H₂S sensor and clinical validation.

ABSTRACT: Exhaled breath analysis offers a painless window into airway inflammation, yet its clinical adoption is limited by a shortage of robust biomarkers. Hydrogen sulfide ([Formula: see text]) has been detected in biological fluids, but its diagnostic value across asthma severities is not well established. In this study, we integrated an electrochemical [Formula: see text] sensor with a detection limit of 1 ppb into the MISTRAL platform. We evaluated exhaled [Formula: see text] in a prospective cohort of 28 adult asthmatic patients. Mean exhaled [Formula: see text] concentrations were significantly higher in individuals with mild-to-moderate asthma ([Formula: see text]) than in those with severe asthma ([Formula: see text]; one‑tailed t‑test [Formula: see text], [Formula: see text]). In early-st

SUBMITTER: Germinario R 

PROVIDER: S-EPMC12830812 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature