Mice carrying nonsense mutant p53 develop frequent multicentric or metastatic tumors.

ABSTRACT: The TP53 tumor suppressor gene is mutated in a large fraction of human tumors. Close to 11% of TP53 mutations are nonsense mutations, causing premature termination of protein synthesis and expression of truncated inactive p53 protein. The most common TP53 nonsense mutation in human cancer is R213X. To study the impact of TP53 nonsense mutations in vivo, we generated mice harboring the Trp53 nonsense mutation R210X that corresponds to human TP53-R213X. Initially, Trp53^R210X mice appear phenotypically normal, although the proportion of female Trp53^R210X/R210X mice is dramatically reduced. Female homozygous mice are poor breeders and remain smaller and lighter than female heterozygous and wildtype littermates. Trp53^R210X/R210X mice start to show tumors at 2.5

SUBMITTER: Strandgren C 

PROVIDER: S-EPMC12830816 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature