Comprehensive analysis of malignant subtypes of lung adenocarcinoma based on multi-omics landscape and functional validation of prognostic biomarker BAIAP2L2.

ABSTRACT: Lung adenocarcinoma, the predominant pathogenic type of lung cancer, exhibits intricate biological behaviors and molecular pathways, which have consistently been a focal point and challenge in tumor research. The integration of multi-omics technologies and diverse analytical methodologies facilitates an in-depth study of lung adenocarcinoma's characteristics at cellular, molecular, and clinical dimensions, providing a theoretical foundation and prospective targets for precise diagnosis and effective treatment. scRNA-seq and RNA-seq data were obtained from public databases. The epithelial cells of lung adenocarcinoma were analyzed by methods such as CNV level assessment, cell trajectory analysis, malignant cell identification, and cell communication analysis, and the marker genes of maligna

SUBMITTER: Jiang B 

PROVIDER: S-EPMC12830839 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature