Glioblastoma zebrafish Avatars guide therapeutic decisions in a patient with gliosarcoma: a case report.

ABSTRACT:

Background

Glioblastoma is the most common and lethal brain tumor. Therapeutic options after recurrence are scarce and with no agreement as to which treatment to offer. Also, no functional tests are currently in use to guide clinical decisions. As a result, patients often undergo multiple treatments, being exposed to toxicities and wasting valuable time.

Methods

Here we report a case of a 37-year-old man with a left temporal glioblastoma (gliosarcoma subtype), who underwent several surgeries and treatments. Tumor DNA sequencing revealed no actionable mutations. At the second recurrence, brain MRI showed three new left-hemisphere nodular lesions, leading to a third surgery. However, twenty-days post-surgery the patient relapsed. Therapeutic options available for this patient

SUBMITTER: Fontes M 

PROVIDER: S-EPMC12830853 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature