Omega-3 fatty acid supplementation does not attenuate declines in skeletal muscle mitochondrial area in young, healthy females during immobilization.

ABSTRACT: Mitochondrial subcellular area influences function. Muscle disuse reduces mitochondrial content; however, its effect on mitochondrial subcellular location is unclear. Omega-3 fatty acid (n-3) attenuates declines in muscle mass and mitochondrial function during disuse; however, whether n-3 supplementation prevents the decline in mitochondrial content has not been examined. We investigated the effects of 2 weeks of leg immobilization followed by 2 weeks of remobilization on skeletal muscle mitochondrial content and subcellular localization with and without n-3 supplementation. Twenty healthy females supplemented with n-3 (2.97 g EPA and 2.03 g DHA) or control (isoenergetic sunflower oil) during 2 weeks of unilateral leg immobilization and 2 weeks of remobilization. Vastus lateralis biopsies

SUBMITTER: Lo MM 

PROVIDER: S-EPMC12830871 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature