Independent inner cell mass and trophectoderm morphology as non-invasive predictors of embryo euploidy in IVF.

ABSTRACT: This study evaluates the independent correlation between inner cell mass (ICM) and trophectoderm (TE) grading with preimplantation genetic testing for aneuploidy (PGT-A) outcomes in embryos biopsied on Day 5 or Day 6 to determine whether morphology-based selection can serve as an alternative to PGT-A. A retrospective analysis of 1,292 embryos from patients undergoing IVF at a single academic center was conducted between October 2019 and March 2023. Blastocysts were graded using Society for Assisted Reproductive Technology (SART) morphology criteria, and biopsy results were categorized as euploid, aneuploid, mosaic, inconclusive, or low DNA. Maternal age (24-45 years) was analyzed both by SART age groups (< 35, 35-37, 38-40, 41-42, > 42) and in a multivariable logistic regression (euploid v

SUBMITTER: Piekos P 

PROVIDER: S-EPMC12830879 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature