Structure of the G_q-coupled adhesion receptor ADGRL4.

ABSTRACT: Adhesion G protein-coupled receptors (aGPCRs) are a 32-member family of Class B GPCRs that have diverse cellular roles including mechanosensation, cell-fate determination, neurodevelopment, immune function and tumour biology. ADGRL4 is upregulated in the tumour microenvironment and is implicated in tumour pathogenesis across a broad range of malignancies. Inhibiting ADGRL4 is a potential therapeutic treatment for currently intractable cancers such as glioblastoma. Previous work suggested that ADGRL4 does not signal through G protein coupled pathways. However, using a sensitive bioluminescent assay, we demonstrate here that ADGRL4 couples weakly to the heterotrimeric G protein G_q, whilst there is no robust coupling to other G proteins (G_s, G₁₂, G_o

SUBMITTER: Chen Q 

PROVIDER: S-EPMC12830901 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature