CircPPFIA2 drives prostate cancer progression and enzalutamide resistance by sponging miR-646 and miR-1200 to upregulate ETS1.

ABSTRACT: Prostate cancer (PCa) represents a leading cause of cancer-related morbidity in men worldwide, necessitating deeper insights into its molecular drivers. Circular RNAs (circRNAs) are increasingly recognized as key regulatory molecules in carcinogenesis; however, their functional significance in PCa pathogenesis and treatment resistance remains incompletely defined. Here, we identify circPPFIA2 as a novel clinically relevant oncogenic circRNA with dual roles in PCa progression and therapeutic resistance. CircPPFIA2 is markedly upregulated in PCa clinical specimens and cell lines. Through gain- and loss-of-function experiments in both cell-based and animal models, we established that circPPFIA2 drives oncogenic phenotypes by enhancing tumor cell proliferation, migratory capacity, and resistan

SUBMITTER: Mao Y 

PROVIDER: S-EPMC12830911 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature