Conserved small RNA networks link inflammation to pain signaling in mice and men.

ABSTRACT: Inflammation can lead to pain, but the underlying mechanisms remain unclear. Here, we identify small non-coding RNA (sncRNA) signatures including microRNAs (miRs) and transfer RNA fragments (tRFs) that may drive inflammatory pain in both acute and chronic settings. Using lipopolysaccharide (LPS)-induced inflammation in murine trigeminal (sensory) and superior cervical (sympathetic) ganglia, we observed temporally distinct alterations in miR and tRF expression. These inflammatory changes overlapped with sncRNA profiles detected in fibromyalgia syndrome (FMS) patient blood cells and keratinocytes, identifying a conserved set of pain-related sncRNAs. Cross-species analyses revealed two oppositely correlated sncRNA clusters whose ratio distinguished inflammatory from control states and progres

SUBMITTER: Madrer N 

PROVIDER: S-EPMC12830950 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature