Anomalous Differences Between the Global Lung Function Initiative 2023 and 2012 Spirometry Reference Values.

ABSTRACT:

Background

In 2012, the Global Lung Function Initiative (GLI) collected a large international database of spirometry measurements in healthy people from which predicted spirometric values were derived based on sex, age, and height for people from 4 different geographic ancestral groups. In 2023, a single set of predicted spirometry values was developed for the entire data set, designed to be independent of ancestry.

Research question

What impact do differences in the proportion of participants from the 4 ancestral groups at each age cohort of the GLI database have on differences between predicted values using the 2012 and 2023 equations?

Study design and methods

Because 77.4% of participants in the GLI spirometry database are of broadly European ancestry, the GLI 2023

SUBMITTER: Graham BL 

PROVIDER: S-EPMC12831081 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature