Beryllium Lymphocyte Proliferation Test: Differential Diagnosis of Sarcoidosis and Chronic Beryllium Disease.

ABSTRACT:

Background

Chronic beryllium disease (CBD) is considered a phenocopy of sarcoidosis, generally caused by occupational exposure to beryllium. Its diagnosis relies on the demonstration of beryllium sensitization by the beryllium lymphocyte proliferation test (BeLPT).

Research question

How well does the BeLPT discriminate between CBD and sarcoidosis in patients with suspected beryllium exposure and what are the clinical characteristics of these 2 groups?

Study design and methods

BeLPT results and clinical characteristics of patients with suspected beryllium exposure were retrospectively analyzed.

Results

A total of 1,234 BeLPTs from 431 patients were included. Of 210 patients with established granulomatous disease, 87 patients (41.4%) were diagnosed with CBD and 1

SUBMITTER: Jouanjan L 

PROVIDER: S-EPMC12831088 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature