Differential Neural Dynamics in Psychomotor Retardation and Agitation of Depression.

ABSTRACT: Psychomotor disturbances like agitation and retardation are key symptoms of major depressive disorder (MDD). Despite their clinical significance, the underlying neural mechanisms, for example, motor or psychomotor, remain yet elusive. This study aimed to investigate whether psychomotor agitation and retardation in MDD are associated with alterations in brain dynamics. A total of 119 patients with MDD and 94 HCs were recruited and undertaken fMRI testing. Brain dynamics was measured by the time delays, the lag propagation of global to somatomotor network (SMN) resting state functional connectivity (FC, e.g., lag propagation). Lag propagation of global to SMN FC was delayed in retarded MDD compared to both agitated MDD (t = 3.256, pFDR = 0.006) and HC (t = 2.493, pFDR = 0.041). Further, we o

SUBMITTER: Liang Q 

PROVIDER: S-EPMC12831119 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature