Olink Proteomic Profiling of Vitreous Humor and Plasma From Proliferative Diabetic Retinopathy Patients Identifies a Novel Inflammatory Molecular Endotype.

ABSTRACT:

Purpose

To characterize proteomic profiles and underlying biological processes in vitreous humor and plasma of patients with proliferative diabetic retinopathy (PDR), diabetic patients without retinopathy (Non_DR), and non-diabetes mellitus patients (Non_DM), and to identify the molecular endotypes within PDR patients.

Methods

Proteomic profiling of paired vitreous humor and plasma samples from 47 PDR patients, 26 Non_DR patients, and 48 Non_DM patients were conducted with Olink platform. The Olink platform includes 13 panels targeting 1161 proteins. Gene set enrichment analysis was applied for enriched pathways, and the K-means clustering method was used to identify different PDR clusters based on vitreous proteomic profiles.

Results

Proteomic analysis revealed signi

SUBMITTER: Lv K 

PROVIDER: S-EPMC12831140 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature