Cellular-Scale Photoreceptor Remodeling After Macular Hole Surgery Examined by Adaptive Optics Optical Coherence Tomography.

ABSTRACT:

Purpose

To investigate outer retinal remodeling at the cellular level after macular hole (MH) surgery using adaptive optics optical coherence tomography (AO-OCT) and to assess the potential clinical relevance of transient hyper-reflective bodies (HRBs) newly observed within the outer nuclear layer (ONL).

Methods

High-resolution AO-OCT was used to longitudinally assess the outer retinal microstructure in 12 eyes from 11 patients with idiopathic MH who underwent successful vitrectomy. The integrity of the photoreceptor inner segment (IS), outer segment (OS), ellipsoid zone, visibility of photoreceptor nuclei in the ONL, and the presence and positional changes of discrete HRBs were evaluated.

Results

All eyes exhibited IS and OS disruptions, focal loss of photoreceptor n

SUBMITTER: Hama Y 

PROVIDER: S-EPMC12831147 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature