Multiple Maternal Chronic Conditions and Risk of Severe Neonatal Morbidity and Mortality.

ABSTRACT:

Importance

Nearly 16% of pregnant individuals have multiple chronic conditions (MCC), and the risk of severe maternal morbidity and mortality increases in a dose-response manner with the number of preexisting conditions. However, little is known about newborn outcomes in this population.

Objective

To examine the association of the number of preexisting maternal chronic conditions, as well as the presence of MCC complexity, cardiometabolic MCC, and MCC severity, with the risk of severe neonatal morbidity or mortality (SNM-M).

Design, setting, and participants

This population-based cohort study was conducted in Ontario, Canada, among all live births from 2012 to 2021. Data were analyzed from September 2024 to November 2025.

Exposure

Maternal MCC measured in the 2

SUBMITTER: Brown HK 

PROVIDER: S-EPMC12831157 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature