What does "success" look like in compliance check decisions by the European Chemicals Agency? The curious cases of accepted read-across adaptations.

ABSTRACT: Under the European Union’s REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) regulation, the European Chemicals Agency (ECHA) is required to assess the compliance of safety data submitted by chemical registrants. ECHA must check a proportion of registration dos­siers for compliance. From 2010 to 2023, 4,854 compliance checks (CCHs) were conducted. When dossiers lack required studies or use inappropriate adaptations, ECHA issues decisions that are publicly available. As of April 2, 2024, 2,311 such decisions had been published. This study sys­tematically analyzed these published CCH decisions, focusing on ECHA’s findings of non-compliant REACH registrations and the use of adaptations to standard information requirements. We found that over 70% of published CCH dec

SUBMITTER: Roe HM 

PROVIDER: S-EPMC12831182 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature